The scientific community is busily making new discoveries about the cannabis plant on an almost daily basis. Some recent research conducted by neuroscientists reveals the mechanism behind weed tolerance. It also shows how the brain does not need much time to return to full normalcy once again. Therefore, it is possible to build up a tolerance to cannabis, but it is quite easy to undo it, as well.
Study into Cannabis Tolerance
The U.S. National Library of Medicine published a study recently that shows how you become tolerant of marijuana and how long, roughly, it takes that tolerance to go away. Authored by Deepak Cyril D’Souza, et al, who is a marijuana expert from Yale University’s School of Medicine, the study was a collaborative effort between prestigious organizations, namely the Harvard School Massachusetts General Hospital, the New York University Langone Medical Center, the Yale University School of Medicine, and the Schizophrenia and Neuropharmacology Research Group of the Connecticut Healthcare System.
Understanding Cannabis Tolerance
Tolerance to weed is not a new emergence. People have had to consume more marijuana than they did the first time to feel the same effects. Although much like opiates in this way, unlike opiates, it is very difficult to overdose on THC, which only becomes toxic when the body contains incredibly high levels of it. Impossibly high, in fact. You would need to consume mounds of THC in one sitting for it to be lethal.
Although weed lovers may have to consume more and more as time marches forward, unlike most other drugs, the tolerance never reaches out-of-control levels. You could puff the same amount of pot every single day your whole life and still feel stoned, just perhaps not as stoned. This study used “cannabis dependent” males aged between 18-years and 35-years old.
The goal was to analyze a radiotracer ligand for cannabinoid receptor 1, or just CB1, the primary receptor triggered by THC to induce its psychoactive effects. To do this, the team used positron emission topography, or a PET scan. The PET is capable of identifying exactly where CB1 receptors are within the brain, as well as how densely they populate different regions of the brain.
Resolving Cannabis Tolerance
The study’s findings were certainly interesting: “In chronic moderate daily cannabis smokers, CB1 receptor availability is decreased in most brain regions. Significant CB1 receptor upregulation begins within two days of abstinence and continues over four weeks.” Simply put, weed lovers have fewer CB1 receptors in the brain than non-users do. Within two days, levels begin rising again and are nearly normal a month later. The less CB1 receptors in the brain, the greater your tolerance to weed.
There was one glitch in the study. The authors noted that the lack of total normalcy of CB1 receptor levels after four weeks could be because they failed to assess initial levels adequately prior to participants abstaining. They noted another drawback in only assessing male subjects and not females too. THC affects women differently to men, which could lie in differential expression of CB receptors.
To avoid such variables, the team only studied men, but they pointed out that future studies of a similar nature should also include women, and that they should monitor potential cognitive changes during the abstinence period, as well. Nevertheless, the study found cannabis smokers with approximately 20 percent less CB1 receptors in the brain than non-imbibing control subjects.
Of particular interest, the quantity of marijuana consumed on a frequent basis had no correlation with the downregulation of CB1 receptor levels. No matter how much someone consumes, it still takes roughly two days of abstinence for CB1 receptor levels to start returning to normal. After four weeks of abstaining, the PET scans found no statistical differences between users and non-users.
This latest finding by D’Souza and his team has other implications, as well, particularly for medical patients using marijuana for its neurological effects, as opposed to its physical ones. Patients suffering with anxiety or post-traumatic stress disorder should know that abstaining for less than a week will reduce buildup tolerance significantly, and when they return from their break, they should go slowly.
Overnight Marijuana Delivery California
If you are considering a break from your toking, then it cannot hurt to abstain for a solid month or two. However, your brain’s CB1 receptors do not require so much time to start returning to normal, just two days. You can order overnight marijuana delivery anywhere in California and get it the next business day. Just enough time to reduce your tolerance somewhat so that bong really hits you.